Glucocorticoid chronotherapy: a mini-review
نویسندگان
چکیده
This year’s Noble Prize in Physiology or Medicine was awarded to Jeffrey C. Hall, Michael Rosbash and Michael Young, for discovering “key genetic gears”of the body’s 24 hour biological clock. Their work identified genes and proteins, that work together in humans and animals to synchronize activities throughout the day and night, regulating sleep patterns, eating habits, blood pressure and hormones, in circadian rythms.1 Another Noble Prize in Physiology and Medicine was awarded in 1950 to Philip S. Hench, for his landmark discovery of the benficial effects of glucocorticoids in rheumatoid arthritis (RA).2
منابع مشابه
Glucocorticoids and chronotherapy in rheumatoid arthritis.
It is evident that the morning symptoms of rheumatoid arthritis (RA) are linked to the circadian abnormal increase in night inflammation, favoured by inadequate cortisol secretion under conditions of active disease. Therefore, exogenous glucocorticoid treatment is recommended in RA at low doses since it may partially act like a 'replacement therapy'. The prevention/treatment of the night upregu...
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Morning symptoms of rheumatoid arthritis (RA) are linked to circadian increase of night inflammation, supported by inadequate cortisol secretion in active disease. Therefore, exogenous glucocorticoid administration in RA is recommended by EULAR and ACR from the beginning of the diagnosis, since may partially act like a "replacement therapy". In addition, the prevention/treatment of the night up...
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The hypothalamic-pituitary-adrenal (HPA) axis plays an important role in regulating and controlling immune responses. Dysfunction of the HPA axis has been implicated in the pathogenesis of rheumatoid arthritis (RA) and other rheumatic diseases. The impact of glucocorticoid (GC) therapy on HPA axis function also remains a matter of concern, particularly for longer treatment duration. Knowledge o...
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OBJECTIVE This 9-month open-label extension of the Circadian Administration of Prednisone in Rheumatoid Arthritis Study (CAPRA 1) investigated the long-term safety and efficacy of prednisone chronotherapy with a novel modified-release (MR) prednisone for up to 12 months. METHODS Of 288 patients with rheumatoid arthritis originally randomised to MR or immediate-release (IR) prednisone, 249 con...
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Glucocorticoids have been belonged to the most widely and commonly used immune modulatory drugs in autoimmune and inflammatory conditions. The anti-inflammatory and immune suppressant mechanisms have been described. However, the glucocorticoids have paracrine and autocrine manner, acting at local tissue level and that is called as “tissue-specific” glucocorticoids. Those have a significant role...
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